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"Creatine has no known physiological effects" The FDA's recent blast at Krebiozen as being "nothing but creatine" is of interest in view of the following item - a letter which appeared in Science (17 November, 1964, p. 1113). Pre-1962 Creatine sought. We are seeking help in finding 50 grams of Eastman (Distillation Products Corporation) creatine, catalog No. 951, purchased prior to 1962. We have been informed that the source of the creatine sold by Eastman has changed, and we find a different physiological response from that formerly found in rats fed creatine. Eastman has been unable to locate a supply of the earlier product for us. W. R. Todd, Department of Biochemistry, University of Oregon Medical School, Portland. Whether there has been an impurity in the old which is not in the new, or vice versa, seems to be undetermined at this point. But of course, both lots were sold as being "nothing but creatine". The rats appear to have considered otherwise. September 1965 |